Heroines Mallory, Vena Cava and Talking Tina fight the fallen angel Abaddon and his accomplices vampire Lady Valentine and succubus Morphine.
Mallory is the head of an elite government-run strike force dedicated to combating the supernatural. Her team includes the drag queen Vena Cava, an explosives expert; a mute, pre-teen telepath capable of possessing others named Talking Tina; and an armed governmental agent named Durand.